MicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4

نویسندگان

  • Hongxia Zhang Department of Internal Medicine, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, 257034, P. R. China
  • Linna Wang Department of Internal Medicine, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, 257034, P. R. China
  • Xiaoning Zhang Department of Internal Medicine, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, 257034, P. R. China
  • Xiaoying Yuan Department of Internal Medicine, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, 257034, P. R. China
  • Ying Xiao Department of Internal Medicine, Shengli Oilfield Central Hospital, Dongying City, Shandong Province, 257034, P. R. China
چکیده مقاله:

Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microRNA 205 (miR-205) in cisplatin-induced renal cell apoptosis and explored the molecular mechanisms. Materials and Methods:The chronic interstitial nephropathy rat model was induced, and the miRNA expression profile in the kidney cells from rats with CKD was screened. Cisplatin-induced apoptosis in normal renal HK-2 cells was evaluated using flow cytometry, and regulation of miR-205 on target gene was validated using luciferase assay, western blot and real time PCR assays. Results: We found that miR-205 expression was significantly decreased in the cells from kidney of CKD rat (P

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عنوان ژورنال

دوره 18  شماره 10

صفحات  1020- 1026

تاریخ انتشار 2015-10-01

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